Centro Escolar University community witnessed the birth of a campus in June 2005 located in the central business district of the National Capital Region at 259-263 Sen. Gil Puyat Avenue, Makati City. Subsequently after two years of operation, the CEU built another unit, which opened on June 2007 at 103 Esteban corner Dela Rosa Streets, Legaspi Village, Makati City. These two units were established to meet the growing demand for higher education from Metro Manila and other prospective applicants from the South.
The Makati Campus is CEU's response to the increasing demand for health professional and non-science courses for which the University has been known during 100 years of existence. The Master of Business Administration program was also offered to make it accessible for the employees of various business corporations in Makati City. Subscribing to the university's educational philosophy of "science and virtue", CEU at Makati is determined to produce globally competent professionals imbued with wholesome values and attitudes.